Structural Insights into Polyhydroxyalkanoates Biosynthesis.
Trends Biochem Sci
; 43(10): 790-805, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30139647
ABSTRACT
Polyhydroxyalkanoates (PHAs) are diverse biopolyesters produced by numerous microorganisms and have attracted much attention as a substitute for petroleum-based polymers. Despite several decades of study, the detailed molecular mechanisms of PHA biosynthesis have remained unknown due to the lack of structural information on the key PHA biosynthetic enzyme PHA synthase. The recently determined crystal structure of PHA synthase, together with the structures of acetyl-coenzyme A (CoA) acetyltransferase and reductase, have changed this situation. Structural and biochemical studies provided important clues for the molecular mechanisms of each enzyme as well as the overall mechanism of PHA biosynthesis from acetyl-CoA. This new information and knowledge is expected to facilitate production of designed novel PHAs and also enhanced production of PHAs.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Poli-Hidroxialcanoatos
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2018
Tipo de documento:
Article