Task-evoked functional connectivity does not explain functional connectivity differences between rest and task conditions.
Hum Brain Mapp
; 39(12): 4939-4948, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30144210
ABSTRACT
During complex tasks, patterns of functional connectivity differ from those in the resting state. However, what accounts for such differences remains unclear. Brain activity during a task reflects an unknown mixture of spontaneous and task-evoked activities. The difference in functional connectivity between a task state and the resting state may reflect not only task-evoked functional connectivity, but also changes in spontaneously emerging networks. Here, we characterized the differences in apparent functional connectivity between the resting state and when human subjects were watching a naturalistic movie. Such differences were marginally explained by the task-evoked functional connectivity involved in processing the movie content. Instead, they were mostly attributable to changes in spontaneous networks driven by ongoing activity during the task. The execution of the task reduced the correlations in ongoing activity among different cortical networks, especially between the visual and non-visual sensory or motor cortices. Our results suggest that task-evoked activity is not independent from spontaneous activity, and that engaging in a task may suppress spontaneous activity and its inter-regional correlation.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Descanso
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Percepção Visual
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Córtex Cerebral
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Conectoma
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Rede Nervosa
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2018
Tipo de documento:
Article