Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications.
Chem Soc Rev
; 47(19): 7401-7425, 2018 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-30175827
ABSTRACT
Synthetic polypeptides derived from the ring-opening polymerization of N-carboxyanhydrides can spontaneously fold into stable secondary structures under specific environmental conditions. These secondary structures and their dynamic transitions play an important role in regulating the properties of polypeptides in self-assembly, catalysis, polymerization, and biomedical applications. Here, we review the current strategies to modulate the secondary structures, and highlight the conformation-specific dynamic properties of synthetic polypeptides and the corresponding materials. A number of mechanistic studies elucidating the role of secondary structures are discussed, aiming to provide insights into the new designs and applications of synthetic polypeptides. We aim for this article to bring to people's attention synthetic polymers with ordered conformations, which may exhibit association behaviors and material properties that are otherwise not found in polymers without stable secondary structures.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Ácidos Carboxílicos
/
Anidridos
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Chem Soc Rev
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos