Isoxazolopyrimidine-Based Inhibitors of <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase with Antimalarial Activity.

Kokkonda, Sreekanth; El Mazouni, Farah; White, Karen L; White, John; Shackleford, David M; Lafuente-Monasterio, Maria Jose; Rowland, Paul; Manjalanagara, Krishne; Joseph, Jayan T; Garcia-Pérez, Adolfo; Fernandez, Jorge; Gamo, Francisco Javier; Waterson, David; Burrows, Jeremy N; Palmer, Michael J; Charman, Susan A; Rathod, Pradipsinh K; Phillips, Margaret A

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity.

Kokkonda, Sreekanth; El Mazouni, Farah; White, Karen L; White, John; Shackleford, David M; Lafuente-Monasterio, Maria Jose; Rowland, Paul; Manjalanagara, Krishne; Joseph, Jayan T; Garcia-Pérez, Adolfo; Fernandez, Jorge; Gamo, Francisco Javier; Waterson, David; Burrows, Jeremy N; Palmer, Michael J; Charman, Susan A; Rathod, Pradipsinh K; Phillips, Margaret A.

Afiliação

Kokkonda S; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.
El Mazouni F; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.
White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
White J; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.
Shackleford DM; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.
Rowland P; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.
Manjalanagara K; Syngene International Ltd, Bangalore 560 099, India.
Joseph JT; Syngene International Ltd, Bangalore 560 099, India.
Garcia-Pérez A; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.
Fernandez J; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.
Gamo FJ; Tres Cantos Medicines Development Campus, GSK, Severo Ochoa, Madrid 28760, Spain.
Waterson D; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.
Burrows JN; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.
Palmer MJ; Medicines for Malaria Venture, 20, Route de Pré-Bois, 1215 Geneva, Switzerland.
Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Rathod PK; Departments of Chemistry and Global Health, University of Washington, Seattle, Washington 98195, United States.
Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390-9038, United States.

ACS Omega ; 3(8): 9227-9240, 2018 Aug 31.

Article em En | MEDLINE | ID: mdl-30197997

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: ACS Omega Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos