Insights into endotoxin-mediated lung inflammation and future treatment strategies.
Expert Rev Respir Med
; 12(11): 941-955, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30221563
ABSTRACT
INTRODUCTION:
Airway inflammatory disorders are prevalent diseases in need of better management and new therapeutics. Immunotherapies offer a solution to the problem of corticosteroid resistance. Areas covered The current review focuses on lipopolysaccharide (Gram-negative bacterial endotoxin)-mediated inflammation in the lung and the animal models used to study related diseases. Endotoxin-induced lung pathology is usually initiated by antigen presenting cells (APC). We will discuss different subsets of APC including lung dendritic cells and macrophages, and their role in responding to endotoxin and environmental challenges. Expert commentary The pharmacotherapeutic considerations to combat airway inflammation should cost-effectively improve quality of life with sustainable and safe strategies. Selectively targeting APCs in the lung offer the potential for a promising new strategy for the better management and treatment of inflammatory lung disease.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Asma
/
Doença Pulmonar Obstrutiva Crônica
/
Endotoxinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Respir Med
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Austrália