Epac Proteins and Calmodulin as Possible Arrhythmogenesis Trigger in Alcoholic Cardiomyopathy.
Bull Exp Biol Med
; 165(5): 613-616, 2018 Sep.
Article
em En
| MEDLINE
| ID: mdl-30225708
The expression of Epac proteins (exchange protein directly activated by cAMP) and calmodulin (CaM) was assessed by the content of the corresponding mRNA in biopsy specimens of cardiac atrium, left ventricle, and thoracic aorta of rats with alcoholic cardiomyopathy. In the myocardium, overexpression of Ðpac1, ÐÑаÑ2, and СаРmRNA was found. The content of Epac2 mRNA in the left ventricle was elevated by 2.9 times (p=0.000001), in the left atrium by 3.2 times (p=0.00001), in the right atrium by 3 times (p=0.00001). In contrast to the myocardial tissue, the content of CaM mRNA in the thoracic aorta was not increased, but showed a tendency to decrease, when compared to the control values, while the level of Epac1 and Epac2 mRNA was increased. The assumption is made that regulatory proteins Epac and CaM can play a key role in arrhythmogenesis development under conditions of alcoholic cardiomyopathy.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
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Calmodulina
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Cardiomiopatia Alcoólica
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Fatores de Troca do Nucleotídeo Guanina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Federação Russa