Responsive neurostimulation: Review of clinical trials and insights into focal epilepsy.
Epilepsy Behav
; 88S: 11-20, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30243756
ABSTRACT
The responsive neurostimulator (RNS ®, NeuroPace Inc.) has been available clinically since 2013 for the treatment of medically refractory partial epilepsy. Using intracranial electrodes and a cranially implanted device, RNS ® provides on-demand electrical cortical stimulation to reduce seizures. A randomized, multicenter, double-blind clinical trial demonstrated seizure reduction compared with sham stimulation. Seizure reduction was improved and sustained over years in a long-term treatment trial. The RNS ® provides chronic ambulatory electrographic monitoring over years giving unprecedented insight into epilepsy dynamics. Studies to date have looked at the length of time to detecting bilateral seizure onsets in mesial temporal lobe epilepsy (MTLE), demonstrated biorhythms in interictal epileptiform activity over varied time scales, and shown promise in early detection of benefits of adding a new antiepileptic drug. Questions remain as to the boundaries of patient selection and lead placement. "This article is part of the Supplement issue Neurostimulation for Epilepsy."
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Epilepsias Parciais
/
Estimulação Encefálica Profunda
/
Neuroestimuladores Implantáveis
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Epilepsia Resistente a Medicamentos
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Epilepsy Behav
Assunto da revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article