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Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity.
Germuska, M; Chandler, H L; Stickland, R C; Foster, C; Fasano, F; Okell, T W; Steventon, J; Tomassini, V; Murphy, K; Wise, R G.
Afiliação
  • Germuska M; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Chandler HL; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Stickland RC; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Foster C; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Fasano F; Siemens Healthcare Ltd, Frimley, Camberley, UK.
  • Okell TW; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
  • Steventon J; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Tomassini V; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, Cardiff, UK; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Murphy K; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.
  • Wise RG; Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK. Electronic address: wiserg@cardiff.ac.uk.
Neuroimage ; 184: 717-728, 2019 01 01.
Article em En | MEDLINE | ID: mdl-30278214
Dual-calibrated fMRI is a multi-parametric technique that allows for the quantification of the resting oxygen extraction fraction (OEF), the absolute rate of cerebral metabolic oxygen consumption (CMRO2), cerebral vascular reactivity (CVR) and baseline perfusion (CBF). It combines measurements of arterial spin labelling (ASL) and blood oxygenation level dependent (BOLD) signal changes during hypercapnic and hyperoxic gas challenges. Here we propose an extension to this methodology that permits the simultaneous quantification of the effective oxygen diffusivity of the capillary network (DC). The effective oxygen diffusivity has the scope to be an informative biomarker and useful adjunct to CMRO2, potentially providing a non-invasive metric of microvascular health, which is known to be disturbed in a range of neurological diseases. We demonstrate the new method in a cohort of healthy volunteers (n = 19) both at rest and during visual stimulation. The effective oxygen diffusivity was found to be highly correlated with CMRO2 during rest and activation, consistent with previous PET observations of a strong correlation between metabolic oxygen demand and effective diffusivity. The increase in effective diffusivity during functional activation was found to be consistent with previously reported increases in capillary blood volume, supporting the notion that measured oxygen diffusivity is sensitive to microvascular physiology.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética Limite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Consumo de Oxigênio / Encéfalo / Mapeamento Encefálico / Imageamento por Ressonância Magnética Limite: Adult / Female / Humans / Male Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2019 Tipo de documento: Article