Graphene Oxideâ»PEGâ»Protocatechuic Acid Nanocomposite Formulation with Improved Anticancer Properties.
Nanomaterials (Basel)
; 8(10)2018 Oct 11.
Article
em En
| MEDLINE
| ID: mdl-30314340
ABSTRACT
The treatment of cancer through chemotherapy is limited by its toxicity to healthy tissues and organs, and its inability to target the cancer site. In this study, we have designed an anticancer nanocomposite delivery system for protocatechuic acid (PCA) using graphene oxideâ»polyethylene glycol as the nanocarrier, and coated with folic acid (GOâ»PEGâ»PCAâ»FA) for targeting the cancer cells. The designed anticancer delivery system was found to show much better anticancer activity than the free drug PCA against liver cancer HEP-G2 cells and human colon cancer HT-29 cells; at same time, it was found to be less toxic to normal fibroblast 3T3 cells. The folate-coated anticancer delivery system was found to show better activity then the free drug and the uncoated anticancer delivery system. The in vitro release of the PCA was found to be sustained in human physiological pHs, i.e., blood pH 7.4 and intracellular lysosomal pH 4.8. These in vitro findings are highly encouraging for further in vivo evaluation studies.
Texto completo:
1
Bases de dados:
MEDLINE
Idioma:
En
Revista:
Nanomaterials (Basel)
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Malásia