Inhibiting gustatory thalamus or medial amygdala has opposing effects on taste neophobia.
Neurobiol Learn Mem
; 156: 24-32, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-30336209
ABSTRACT
Taste neophobia is a feeding system defense mechanism that limits consumption of an unknown, and therefore potentially dangerous, edible until the post-ingestive consequences are experienced. We found that transient pharmacological inhibition (induced with the GABA agonists baclofen and muscimol) of the gustatory thalamus (GT; Experiment 1), but not medial amygdala (MeA; Experiment 2), during exposure to a novel saccharin solution attenuated taste neophobia. In Experiment 3 we found that inhibition of MeA neurons (induced with the chemogenetic receptor hM4DGi) enhanced the expression of taste neophobia whereas excitation of MeA neurons (with hM3DGq) had no influence of taste neophobia. Overall, these results refine the temporal involvement of the GT in the occurrence of taste neophobia and support the hypothesis that neuronal excitation in the GT is necessary for taste neophobia. Conversely, we show that chemogenetically, but not pharmacologically, inhibiting MeA neurons is sufficient to exaggerate the expression of taste neophobia.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Aprendizagem da Esquiva
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Agonistas GABAérgicos
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Condicionamento Clássico
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Núcleos Ventrais do Tálamo
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Percepção Gustatória
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Complexo Nuclear Corticomedial
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Assunto da revista:
BIOLOGIA
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CIENCIAS DO COMPORTAMENTO
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NEUROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article