Short, Tin-Free Synthesis of All Three Inthomycins.

Kumar, Manjeet; Bromhead, Liam; Anderson, Zoe; Overy, Alistair; Burton, Jonathan W

Kumar, Manjeet; Bromhead, Liam; Anderson, Zoe; Overy, Alistair; Burton, Jonathan W.

Afiliação

Kumar M; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Bromhead L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Anderson Z; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Overy A; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.
Burton JW; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, OX1 3TA, UK.

Chemistry ; 24(63): 16753-16756, 2018 Nov 13.

Article em En | MEDLINE | ID: mdl-30338587

ABSTRACT

ABSTRACT

The inthomycins are a family of structurally and biologically rich natural products isolated from Streptomyces species. Herein the implementation of a modular synthetic route is reported that has enabled the enantioselective synthesis of all three inthomycins. Key steps include Suzuki and Sonogashira cross-couplings and an enantioselective Kiyooka aldol reaction.

Palavras-chave

inthomycin; phthoxazolin; total synthesis

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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