Hydrogen Atom Transfer-Mediated Cyclisations of Nitriles.
Chemistry
; 24(70): 18658-18662, 2018 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-30341926
Hydrogen atom transfer-mediated intramolecular C-C coupling reactions between alkenes and nitriles, using PhSiH3 and catalytic Fe(acac)3 , are described. This introduces a new strategic bond disconnection for ring-closing reactions, forming ketones via imine intermediates. Of note is the scope of the reaction, including formation of sterically hindered ketones, spirocycles and fused cyclic systems.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Chemistry
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article