Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

Wang-Bishop, Lihong; Chen, Zheng; Gomaa, Ahmed; Lockhart, Albert Craig; Salaria, Safia; Wang, Jialiang; Lewis, Keeli B; Ecsedy, Jeffrey; Washington, Kay; Beauchamp, Robert Daniel; El-Rifai, Wael

Wang-Bishop, Lihong; Chen, Zheng; Gomaa, Ahmed; Lockhart, Albert Craig; Salaria, Safia; Wang, Jialiang; Lewis, Keeli B; Ecsedy, Jeffrey; Washington, Kay; Beauchamp, Robert Daniel; El-Rifai, Wael.

Afiliação

Wang-Bishop L; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee.
Chen Z; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Gomaa A; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida.
Lockhart AC; Division of Medical Oncology, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida.
Salaria S; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Wang J; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Lewis KB; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Ecsedy J; Translational Medicine, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts.
Washington K; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Beauchamp RD; Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee.
El-Rifai W; Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami VA Healthcare system, Miami, Florida. Electronic address: welrifai@med.m

Gastroenterology ; 156(3): 662-675.e7, 2019 02.

Article em En | MEDLINE | ID: mdl-30342037

Assuntos

Aurora Quinase A/antagonistas & inibidores; Azepinas/farmacologia; Neoplasias Gastrointestinais/genética; Proteínas Proto-Oncogênicas p21(ras)/genética; Pirimidinas/farmacologia; Animais; Aurora Quinase A/genética; Aurora Quinase A/farmacologia; Morte Celular/efeitos dos fármacos; Morte Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Proliferação de Células/genética; Neoplasias Gastrointestinais/tratamento farmacológico; Neoplasias Gastrointestinais/patologia; Regulação Neoplásica da Expressão Gênica; Humanos; Camundongos; Camundongos Nus; Terapia de Alvo Molecular; Inibidores de Proteínas Quinases/farmacologia; Distribuição Aleatória; Sensibilidade e Especificidade; Transdução de Sinais/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Colon Cancer; Mutation; Oncogenic; Signal Transduction

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Pirimidinas / Azepinas / Proteínas Proto-Oncogênicas p21(ras) / Aurora Quinase A / Neoplasias Gastrointestinais Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2019 Tipo de documento: Article

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