Evaluation of sperm DNA fragmentation index, Zinc concentration and seminal parameters from infertile men with varicocele.
Andrologia
; 51(2): e13184, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30370543
ABSTRACT
The aim of this study was to investigate the effect of varicocele on DNA fragmentation index (DFI), zinc concentration and seminal parameters in infertile patients. In this prospective study, 179 men with at least 1-year history of infertility and varicocele were examined for semen quality at Hanoi Medical University Hospital (HMUH), Hanoi, Vietnam. In addition, an inverse correlation between zinc concentration and the degree of sperm DNA fragmentation in patients with clinical varicocele was found. The difference in mean values of sperm DNA fragmentation index in patients with various grades of varicoceles can be neglected, whereas most patients with varicocele of grades II and III had DFI >30%. Varicocele is associated with high levels of DNA damage in spermatozoa and reduced zinc levels that correlate with different grades of disease. Therefore, DNA fragmentation index and zinc concentration can be used as essential additional diagnostic test for patients with clinical varicocele. A study should be conducted to evaluate the benefits of zinc supplementation to improve seminal parameters in patients with varicocele.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sêmen
/
Espermatozoides
/
Varicocele
/
Zinco
/
Fragmentação do DNA
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Infertilidade Masculina
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Revista:
Andrologia
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Vietnã