Silver carbene complexes: An emerging class of anticancer agents.
Drug Dev Res
; 80(2): 188-199, 2019 03.
Article
em En
| MEDLINE
| ID: mdl-30387164
ABSTRACT
Cancer is a major global health problem with large therapeutic challenges. Although substantial progress has been made in cancer therapy, there still remains a need to develop novel and effective treatment strategies to treat several relapsed and refractory cancers. Recently, there has been growing demand for considering organometallics as antineoplastic agents. This review is focused on a group of organometallics, silver N-heterocyclic carbene complexes (SCCs) and their anticancer efficacy in targeting multiple pathways in various in vitro cancer model systems. However, the precise molecular mechanism of SCCs anticancer properties remains unclear. Here, we discuss the SCCs chemistry, potential molecular targets, possible molecular mechanism of action, and their application in cancer therapies.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Prata
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Complexos de Coordenação
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Metano
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Antineoplásicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Drug Dev Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia