Catalytic Asymmetric Hydrophosphination of ortho-Quinone Methides.
Org Lett
; 20(22): 7229-7233, 2018 11 16.
Article
em En
| MEDLINE
| ID: mdl-30398353
ABSTRACT
An efficient catalytic asymmetric hydrophosphination of ortho-quinone methides with H-phosphine oxides is established. A chiral bifunctional squaramide is superior to catalyze this enantioselective carbon-phosphorus bond formation, delivering optically active α-arylmethyl phosphine oxides in high yields with high enantioselectivities (up to 94% yield, 991 er). Additionally, employing in situ-generated o-QMs for this hydrophosphination step economically provides the corresponding phosphine oxides with comparable yield and enantioselectivity.
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2018
Tipo de documento:
Article