Inhibitory effect of Carnosol on UVB-induced inflammation via inhibition of STAT3.
Arch Pharm Res
; 42(3): 274-283, 2019 Mar.
Article
em En
| MEDLINE
| ID: mdl-30430364
ABSTRACT
Ultraviolet B (UVB) irradiation causes sunburn, inflammatory responses, dysregulation of immune function, oxidative stress, DNA damage and photocarcinogenesis on skin. Rosemary (Rosmarinus officinalis L.) has been reported to inhibit inflammation. Carnosol, a major component of Rosemary, has prominent anti-inflammatory effects. However, its protective effect on UVB-induced inflammatory skin responses has not yet been reported. Here, we investigated the effectiveness of carnosol on UVB-induced inflammation. We examined the anti-inflammation effect of topical application of carnosol (0.05 µg/cm2) on UVB (540 mJ/cm2, for 3 successive days)-induced skin inflammation in HR1 mice. Topical application of carnosol inhibited UVB-induced erythema, epidermal thickness, inflammatory responses in HR1 mice. Carnosol reduced the level of Immunoglobulin-E and IL-1ß in blood serum of UVB-induced mice. Carnosol also significantly inhibited the UVB-induced expression of inflammatory marker protein (iNOS and COX-2) in back skin of mice. In addition, carnosol treated skin decreased activation of STAT3, a transcriptional factor regulating inflammatory genes. Our study suggested that carnosol has protective effects on skin inflammatory skin damages by UVB.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Anti-Inflamatórios não Esteroides
/
Abietanos
/
Fator de Transcrição STAT3
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2019
Tipo de documento:
Article