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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function.
Buchan, Sarah L; Dou, Lang; Remer, Marcus; Booth, Steven G; Dunn, Stuart N; Lai, Chester; Semmrich, Monika; Teige, Ingrid; Mårtensson, Linda; Penfold, Christine A; Chan, H T Claude; Willoughby, Jane E; Mockridge, C Ian; Dahal, Lekh N; Cleary, Kirstie L S; James, Sonya; Rogel, Anne; Kannisto, Päivi; Jernetz, Mats; Williams, Emily L; Healy, Eugene; Verbeek, J Sjef; Johnson, Peter W M; Frendéus, Björn; Cragg, Mark S; Glennie, Martin J; Gray, Juliet C; Al-Shamkhani, Aymen; Beers, Stephen A.
Afiliação
  • Buchan SL; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Dou L; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Remer M; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Booth SG; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Dunn SN; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Lai C; Department of Dermatopharmacology, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, UK; Department of Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
  • Semmrich M; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden.
  • Teige I; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden.
  • Mårtensson L; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden.
  • Penfold CA; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Chan HTC; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Willoughby JE; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Mockridge CI; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Dahal LN; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Cleary KLS; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • James S; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Rogel A; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Kannisto P; Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
  • Jernetz M; Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
  • Williams EL; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Healy E; Department of Dermatopharmacology, University of Southampton, Faculty of Medicine, Southampton SO16 6YD, UK; Department of Dermatology, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
  • Verbeek JS; Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands.
  • Johnson PWM; Cancer Research UK Southampton Centre, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Frendéus B; BioInvent International AB, Sölvegatan 41, 22370 Lund, Sweden.
  • Cragg MS; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Glennie MJ; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK.
  • Gray JC; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK. Electronic address: j.c.gray@soton.ac.uk.
  • Al-Shamkhani A; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK. Electronic address: a.al-shamkhani@soton.ac.uk.
  • Beers SA; Antibody and Vaccine Group, Centre for Cancer Immunology, University of Southampton Faculty of Medicine, Southampton SO16 6YD, UK. Electronic address: sab@soton.ac.uk.
Immunity ; 49(5): 958-970.e7, 2018 11 20.
Article em En | MEDLINE | ID: mdl-30446386
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Linfócitos T CD8-Positivos / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Imunomodulação / Anticorpos Monoclonais / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Linfócitos T Reguladores / Linfócitos T CD8-Positivos / Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral / Imunomodulação / Anticorpos Monoclonais / Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Immunity Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido