Developmental influences on stress response systems: Implications for psychopathology vulnerability in adolescence.
Compr Psychiatry
; 88: 9-21, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30466015
ABSTRACT
The adolescent transition is marked by increases in stress exposure and significant maturation of neural and hormonal stress processing systems. Variability in the development of these systems during adolescence may influence the risk for stress-related psychopathology. This paper aims to review the developmental maturation of the HPA axis and related stress regulation systems, and demonstrate how interference in this adaptive developmental process may increase the risk for negative outcomes. We argue that the developmental maturation of the HPA axis aims to improve the regulatory capacity of the axis in order to more adaptively respond to these increases in stress reactivity. Additionally, we review evidence that sex differences in the development of the HPA and related axes may contribute to sex differences in the risk for stress-related psychopathology. Finally, we discuss how contextual factors, such as early trauma and obesity may alter the development of HPA axis during the adolescence transition and how alterations of normative development increase the risk for stress-related disorders.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sistema Hipófise-Suprarrenal
/
Estresse Psicológico
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Comportamento do Adolescente
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Desenvolvimento do Adolescente
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Sistema Hipotálamo-Hipofisário
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Female
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Humans
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Male
Idioma:
En
Revista:
Compr Psychiatry
Ano de publicação:
2019
Tipo de documento:
Article