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Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons.
Stakenborg, Nathalie; Labeeuw, Evelien; Gomez-Pinilla, Pedro J; De Schepper, Sebastiaan; Aerts, Raymond; Goverse, Gera; Farro, Giovanna; Appeltans, Iris; Meroni, Elisa; Stakenborg, Michelle; Viola, Maria Francesca; Gonzalez-Dominguez, Erika; Bosmans, Goele; Alpizar, Yeranddy A; Wolthuis, Albert; D'Hoore, Andre; Van Beek, Kim; Verheijden, Simon; Verhaegen, Marleen; Derua, Rita; Waelkens, Etienne; Moretti, Milena; Gotti, Cecilia; Augustijns, Patrick; Talavera, Karel; Vanden Berghe, Pieter; Matteoli, Gianluca; Boeckxstaens, Guy E.
Afiliação
  • Stakenborg N; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Labeeuw E; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Gomez-Pinilla PJ; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • De Schepper S; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Aerts R; Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
  • Goverse G; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
  • Farro G; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Appeltans I; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Meroni E; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Stakenborg M; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
  • Viola MF; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Gonzalez-Dominguez E; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Bosmans G; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Alpizar YA; Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium.
  • Wolthuis A; Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
  • D'Hoore A; Department of Abdominal Surgery, University Hospital of Leuven, Leuven, Belgium.
  • Van Beek K; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Verheijden S; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
  • Verhaegen M; Department of Anesthesiology, University Hospital of Leuven, Leuven, Belgium.
  • Derua R; Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium.
  • Waelkens E; Department of Cellular and Molecular Medicine, Laboratory of Protein Phosphorylation and Proteomics, Universitiy of Leuven, Leuven, Belgium.
  • Moretti M; CNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy.
  • Gotti C; CNR, Neuroscience Institute-Milano, Biometra University of Milan, Milan, Italy.
  • Augustijns P; Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Drug Delivery and Disposition, University of Leuven, Leuven, Belgium.
  • Talavera K; Department of Cellular and Molecular Medicine, Laboratory of Ion Channel Research, KU Leuven; VIB Center for Brain & Disease Research, Leuven, Belgium.
  • Vanden Berghe P; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Enteric Neuroscience, University of Leuven, Leuven, Belgium.
  • Matteoli G; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Laboratory for Mucosal Immunology, University of Leuven, Leuven, Belgium.
  • Boeckxstaens GE; Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for GastroIntestinal Disorders, Intestinal Neuroimmune Interactions, University of Leuven, Leuven, Belgium.
Gut ; 68(8): 1406-1416, 2019 08.
Article em En | MEDLINE | ID: mdl-30472681
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Benzofuranos / Pancreaticoduodenectomia / Íleus / Intestino Delgado / Músculo Liso Tipo de estudo: Clinical_trials / Etiology_studies Idioma: En Revista: Gut Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Benzofuranos / Pancreaticoduodenectomia / Íleus / Intestino Delgado / Músculo Liso Tipo de estudo: Clinical_trials / Etiology_studies Idioma: En Revista: Gut Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica