The molecular hallmarks of epigenetic effects mediated by antiepileptic drugs.
Epilepsy Res
; 149: 53-65, 2019 01.
Article
em En
| MEDLINE
| ID: mdl-30476813
ABSTRACT
Epilepsy is associated with several epigenetic changes, such as DNA methylation, histone modification, and alterations in the synthesis and functioning of non-coding RNAs (ncRNAs). Paradoxically, antiepileptic drugs (AEDs) that are widely used to control epilepsy may also induce epigenetic modifications and alter the structure of chromatin. As a consequence, changes in the expression of various factors involved in the pathology of epilepsy may positively or negatively affect the course of the disease. It should be noted that while AEDs are widely used in the treatment of epilepsy and other neurological disorders, many of their epigenetic consequences are still unknown. Moreover, an improved understanding of AED-induced epigenetic alterations could provide new targets for future therapeutic interventions. In this review, we give a general overview of the current scientific evidence concerning the epigenetic effects of AEDs that are currently in clinic use and have been evaluated to date.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Epigênese Genética
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Epilepsia
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Anticonvulsivantes
Limite:
Animals
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Humans
Idioma:
En
Revista:
Epilepsy Res
Assunto da revista:
CEREBRO
/
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article