CHESS: a new human gene catalog curated from thousands of large-scale RNA sequencing experiments reveals extensive transcriptional noise.
Genome Biol
; 19(1): 208, 2018 11 28.
Article
em En
| MEDLINE
| ID: mdl-30486838
ABSTRACT
We assembled the sequences from deep RNA sequencing experiments by the Genotype-Tissue Expression (GTEx) project, to create a new catalog of human genes and transcripts, called CHESS. The new database contains 42,611 genes, of which 20,352 are potentially protein-coding and 22,259 are noncoding, and a total of 323,258 transcripts. These include 224 novel protein-coding genes and 116,156 novel transcripts. We detected over 30 million additional transcripts at more than 650,000 genomic loci, nearly all of which are likely nonfunctional, revealing a heretofore unappreciated amount of transcriptional noise in human cells. The CHESS database is available at http//ccb.jhu.edu/chess .
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
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Análise de Sequência de RNA
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Bases de Dados Genéticas
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Genome Biol
Assunto da revista:
BIOLOGIA MOLECULAR
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GENETICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos