The dual role of KCNQ/M channels upon OGD or OGD/R insults in cultured cortical neurons of mice: Timing is crucial in targeting M-channels against ischemic injur ies.

Diao, Yu; Yan, Weijie; Sun, Wei; Luo, Yanlin; Li, Junfa; Yin, Yanling

Diao, Yu; Yan, Weijie; Sun, Wei; Luo, Yanlin; Li, Junfa; Yin, Yanling.

Afiliação

Diao Y; Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yan W; Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Sun W; Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Luo Y; Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Li J; Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Yin Y; Department of Neurobiology, Key Laboratory for Neurodegenerative Disorders of the Ministry of Education, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

J Cell Physiol ; 234(8): 12714-12726, 2019 08.

Article em En | MEDLINE | ID: mdl-30523632

Assuntos

Glucose/metabolismo; Canais de Potássio KCNQ/metabolismo; Neurônios/metabolismo; Oxigênio/metabolismo; Traumatismo por Reperfusão/metabolismo; Animais; Carbamatos/farmacologia; Feminino; Ácido Glutâmico/metabolismo; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Potencial da Membrana Mitocondrial/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Neurônios/efeitos dos fármacos; Fenilenodiaminas/farmacologia

Palavras-chave

KCNQ/Kv7/M-channels; miniature excitatory postsynaptic currents (mEPSCs); nitric oxide (NO); oxygen-glucose deprivation/reperfusion (OGD/R); reactive oxygen species (ROS)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oxigênio / Traumatismo por Reperfusão / Canais de Potássio KCNQ / Glucose / Neurônios Limite: Animals Idioma: En Revista: J Cell Physiol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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