Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-&#945; Identifies Antiviral Proteins Enriched in Exosomes.

Yao, Zhenlan; Jia, Xiaofang; Megger, Dominik A; Chen, Jieliang; Liu, Yuyi; Li, Jianhua; Sitek, Barbara; Yuan, Zhenghong

Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes.

Yao, Zhenlan; Jia, Xiaofang; Megger, Dominik A; Chen, Jieliang; Liu, Yuyi; Li, Jianhua; Sitek, Barbara; Yuan, Zhenghong.

Afiliação

Yao Z; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences , Shanghai Medical College of Fudan University , Shanghai 200032 , China.
Jia X; Shanghai Public Health Clinical Center , Fudan University , Shanghai 201508 , China.
Megger DA; Medizinisches Proteom-Center , Ruhr-Universität Bochum , 44801 Bochum , Germany.
Chen J; Institute for Virology, University Hospital Essen , University Duisburg-Essen , 50 Virchowstraße 179 , 45147 Essen , Germany.
Liu Y; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences , Shanghai Medical College of Fudan University , Shanghai 200032 , China.
Li J; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences , Shanghai Medical College of Fudan University , Shanghai 200032 , China.
Sitek B; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences , Shanghai Medical College of Fudan University , Shanghai 200032 , China.
Yuan Z; Medizinisches Proteom-Center , Ruhr-Universität Bochum , 44801 Bochum , Germany.

J Proteome Res ; 18(3): 855-864, 2019 03 01.

Article em En | MEDLINE | ID: mdl-30550287

Assuntos

Exossomos/química; Imunidade Inata; Interferon-alfa/farmacologia; Macrófagos/metabolismo; Proteômica/métodos; Antivirais/análise; Antivirais/metabolismo; Exossomos/metabolismo; Vírus da Hepatite B/imunologia; Humanos; Imunidade Inata/efeitos dos fármacos; Macrófagos/química; Macrófagos/efeitos dos fármacos; Células THP-1

Palavras-chave

IFN-α; ISGs; exosomes; label-free quantification; macrophages

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Interferon-alfa / Proteômica / Exossomos / Imunidade Inata / Macrófagos Limite: Humans Idioma: En Revista: J Proteome Res Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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