Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities.
Trends Biochem Sci
; 44(4): 351-364, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30555007
ABSTRACT
A protein is a dynamic shape-shifter whose function is determined by the set of structures it adopts. Unfortunately, atomically detailed structures are only available for a few conformations of any given protein, and these structures have limited explanatory and predictive power. Here, we provide a brief historical perspective on protein dynamics and introduce recent advances in computational and experimental methods that are providing unprecedented access to protein shape-shifting. Next, we focus on how these tools are revealing the mechanism of allosteric communication and features like cryptic pockets; both of which present new therapeutic opportunities. A major theme is the importance of considering the relative probabilities of different structures and the control one can exert over protein function by modulating this balance.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Proteínas
/
Biologia Computacional
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos