Circadian blueprint of metabolic pathways in the brain.
Nat Rev Neurosci
; 20(2): 71-82, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30559395
ABSTRACT
The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Química Encefálica
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Ritmo Circadiano
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Redes e Vias Metabólicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos