Current challenges in the development of new treatments for lupus.
Ann Rheum Dis
; 78(6): 729-735, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30636212
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a considerable impact on patients' quality of life. Despite the plethora of clinical trials for SLE since the turn of the millennium, only one new treatment has been approved for the condition, and the overall pace of successful drug development remains slow. Nevertheless, the myriad of clinical studies has yielded insights that have informed and refined our understanding of eligibility criteria, outcome measures and trial design in SLE. In this review, we highlight the achievements of clinical trials as well as the major pitfalls that have been identified in drug development for SLE and, in doing so, identify areas where collaboration and consensus will be important to facilitate progress.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Ann Rheum Dis
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos