Self-assembled organic nanoparticles of benzimidazole analogue exhibit enhanced uptake in 3D tumor spheroids and oxidative stress induced cytotoxicity in breast cancer.

Dhanwal, Vandna; Katoch, Archana; Singh, Amanpreet; Chakraborty, Souneek; Faheem, Mir Mohd; Kaur, Gaganpreet; Nayak, Debasis; Singh, Narinder; Goswami, Anindya; Kaur, Navneet

Dhanwal, Vandna; Katoch, Archana; Singh, Amanpreet; Chakraborty, Souneek; Faheem, Mir Mohd; Kaur, Gaganpreet; Nayak, Debasis; Singh, Narinder; Goswami, Anindya; Kaur, Navneet.

Afiliação

Dhanwal V; Centre for Nanoscience & Nanotechnology (U.I.E.A.S.T), Panjab University, Chandigarh 160014, India; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Katoch A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Singh A; Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Roopnagar, Punjab 140001, India.
Chakraborty S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Faheem MM; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Kaur G; Centre for Nanoscience & Nanotechnology (U.I.E.A.S.T), Panjab University, Chandigarh 160014, India.
Nayak D; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.
Singh N; Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Roopnagar, Punjab 140001, India.
Goswami A; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address: agoswami@iiim.ac.in.
Kaur N; Department of Chemistry, Panjab University, Chandigarh 160014, India. Electronic address: navneetkaur@pu.ac.in.

Mater Sci Eng C Mater Biol Appl ; 97: 467-478, 2019 Apr.

Article em En | MEDLINE | ID: mdl-30678934

Assuntos

Benzimidazóis/química; Nanopartículas/química; Estresse Oxidativo; Apoptose/efeitos dos fármacos; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Feminino; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; NF-kappa B/metabolismo; Nanopartículas/toxicidade; Estresse Oxidativo/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Esferoides Celulares/citologia; Esferoides Celulares/efeitos dos fármacos; Esferoides Celulares/metabolismo

Palavras-chave

3D spheroid uptake; Apoptosis; Benzimidazole; Breast cancer; Organic nanoparticles; Reactive oxygen species (ROS)

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Benzimidazóis / Estresse Oxidativo / Nanopartículas Limite: Female / Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia

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