Exploring immunomodulation by endocrine changes in Lady Windermere syndrome.
Clin Exp Immunol
; 196(1): 28-38, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30697704
Lung disease due to nontuberculous mycobacteria (NTM) occurs with disproportionate frequency in postmenopausal women with a unique phenotype and without clinically apparent predisposing factors. Dubbed 'Lady Windermere syndrome', the phenotype includes low body mass index (BMI), tall stature and higher than normal prevalence of scoliosis, pectus excavatum and mitral valve prolapse. Although the pathomechanism for susceptibility to NTM lung disease in these patients remains uncertain, it is likely to be multi-factorial. A role for the immunomodulatory consequences of oestrogen deficiency and altered adipokine production has been postulated. Altered levels of adipokines and dehydroepiandrosterone have been demonstrated in patients with NTM lung disease. Case reports of NTM lung disease in patients with hypopituitarism support the possibility that altered endocrine function influences disease susceptibility. This paper catalogues the evidence for immunomodulatory consequences of predicted endocrine changes in Lady Windermere syndrome, with emphasis on the immune response to NTM. Collectively, the data warrant further exploration of an endocrine link to disease susceptibility in Lady Windermere syndrome.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Glândulas Endócrinas
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Estrogênios
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Pneumopatias
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Micobactérias não Tuberculosas
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Infecções por Mycobacterium não Tuberculosas
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália