Bispecific Antibodies in Hematologic Malignancies: When, to Whom, and How Should Be Best Used?
Curr Oncol Rep
; 21(2): 17, 2019 02 04.
Article
em En
| MEDLINE
| ID: mdl-30715609
ABSTRACT
PURPOSE OF REVIEW The purpose of this review is to discuss the current recommendations for the use of bispecific antibodies (bsAb) in hematologic malignancies and explore the future in this field. RECENT FINDINGS:
Bispecific antibodies are molecules able to target two different antigen-binding sites one towards a tumor antigen and another to activate a cytotoxic cell. Phase II/III trials on blinatumomab for acute lymphoblastic leukemia (ALL) have demonstrated its efficacy for treating minimal residual disease (MRD+) and relapsed refractory (r/r) Philadelphia positive (Ph+) and negative (Ph-) ALL in adults and children. Currently, the only bispecific antibody (bsAb) approved for its use in hematologic malignancies is blinatumomab. However, multiple trials are under development not only to explore blinatumomab's clinical activity in other neoplasia, such as lymphoma or multiple myeloma, but also to develop new molecules against different antigens.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Anticorpos Biespecíficos
/
Neoplasias Hematológicas
/
Antineoplásicos Imunológicos
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Humans
Idioma:
En
Revista:
Curr Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
México