Low-dose eribulin reduces lung metastasis of osteosarcoma in vitro and in vivo.
Oncotarget
; 10(2): 161-174, 2019 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-30719211
ABSTRACT
Lung metastasis markedly reduces the prognosis of osteosarcoma. Moreover, there is no effective treatment for lung metastasis, and a new treatment strategy for the treatment of osteosarcoma lung metastasis is required. Therefore, in this study, we investigated the suppressive effect of the microtubule inhibitor eribulin mesylate (eribulin) on lung metastasis of osteosarcoma. At concentrations >proliferation IC50, eribulin induced cell cycle arrest and apoptosis in a metastatic osteosarcoma cell line, LM8. However, at concentrations
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Bases de dados:
MEDLINE
Idioma:
En
Revista:
Oncotarget
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão