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A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination.
Ideno, Noboru; Yamaguchi, Hiroshi; Okumura, Takashi; Huang, Jonathon; Brun, Mitchell J; Ho, Michelle L; Suh, Junghae; Gupta, Sonal; Maitra, Anirban; Ghosh, Bidyut.
Afiliação
  • Ideno N; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Yamaguchi H; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Okumura T; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Huang J; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Brun MJ; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
  • Ho ML; Department of Bioengineering, Rice University, Houston, TX, USA.
  • Suh J; Department of Bioengineering, Rice University, Houston, TX, USA.
  • Gupta S; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA.
  • Maitra A; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA. amaitra@mdanderson.org.
  • Ghosh B; Department of Translational Molecular Pathology and Sheikh Ahmed Pancreatic Cancer Research Center, UT MD Anderson Cancer Center, Houston, TX, USA. bghosh@mdanderson.org.
Lab Invest ; 99(8): 1233-1244, 2019 07.
Article em En | MEDLINE | ID: mdl-30728464

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Recombinação Genética / Sistemas CRISPR-Cas / Edição de Genes / Neoplasias Experimentais Limite: Animals / Humans Idioma: En Revista: Lab Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Recombinação Genética / Sistemas CRISPR-Cas / Edição de Genes / Neoplasias Experimentais Limite: Animals / Humans Idioma: En Revista: Lab Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos