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Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma.
Cloughesy, Timothy F; Mochizuki, Aaron Y; Orpilla, Joey R; Hugo, Willy; Lee, Alexander H; Davidson, Tom B; Wang, Anthony C; Ellingson, Benjamin M; Rytlewski, Julie A; Sanders, Catherine M; Kawaguchi, Eric S; Du, Lin; Li, Gang; Yong, William H; Gaffey, Sarah C; Cohen, Adam L; Mellinghoff, Ingo K; Lee, Eudocia Q; Reardon, David A; O'Brien, Barbara J; Butowski, Nicholas A; Nghiemphu, Phioanh L; Clarke, Jennifer L; Arrillaga-Romany, Isabel C; Colman, Howard; Kaley, Thomas J; de Groot, John F; Liau, Linda M; Wen, Patrick Y; Prins, Robert M.
Afiliação
  • Cloughesy TF; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu.
  • Mochizuki AY; Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu.
  • Orpilla JR; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. tcloughesy@mednet.ucla.edu.
  • Hugo W; Division of Hematology/Oncology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Lee AH; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Davidson TB; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Wang AC; Department of Medical and Molecular Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Ellingson BM; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Rytlewski JA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
  • Sanders CM; Division of Hematology/Oncology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Kawaguchi ES; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Du L; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
  • Li G; Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Yong WH; Adaptive Biotechnologies, Seattle, WA, USA.
  • Gaffey SC; Adaptive Biotechnologies, Seattle, WA, USA.
  • Cohen AL; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Mellinghoff IK; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • Lee EQ; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA.
  • Reardon DA; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA.
  • O'Brien BJ; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Butowski NA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Nghiemphu PL; Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
  • Clarke JL; Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Arrillaga-Romany IC; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Colman H; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Kaley TJ; Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • de Groot JF; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Liau LM; Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Wen PY; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
  • Prins RM; Department of Neurology, Massachusetts General Hospital Cancer Center, Boston, MA, USA.
Nat Med ; 25(3): 477-486, 2019 03.
Article em En | MEDLINE | ID: mdl-30742122
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Microambiente Tumoral / Anticorpos Monoclonais Humanizados / Receptor de Morte Celular Programada 1 / Antineoplásicos Imunológicos / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Microambiente Tumoral / Anticorpos Monoclonais Humanizados / Receptor de Morte Celular Programada 1 / Antineoplásicos Imunológicos / Recidiva Local de Neoplasia Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos