Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination.
Hum Vaccin Immunother
; 15(9): 2106-2111, 2019.
Article
em En
| MEDLINE
| ID: mdl-30779678
ABSTRACT
In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.2%. Among students with confirmed vaccination status, 90% had received at least one dose of MuCV. Cases were more likely than non-cases to report taking the school bus during the epidemic period (adjusted OR = 2.3, 95% CI 1.4-3.7). Vaccine effectiveness (VE) was higher for two-dose MuCV (76%, 95% CI49â"89%) than for one-dose MuCV (59%, 95% CI 36â"74%. The protection afforded by both one-dose and two-dose MuCV waned over time, from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE, and from 90% to 25% over the same time period for two-dose VE. We found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV vaccination. Although the VE of both two-dose and one-dose MuCV wanes over time, the overall VE for two-dose MuCV was superior than that of one-dose MuCV. Therefore, a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China.
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Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Estudantes
/
Vacina contra Caxumba
/
Surtos de Doenças
/
Esquemas de Imunização
/
Cobertura Vacinal
/
Caxumba
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
/
Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Hum Vaccin Immunother
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China