Concordance for Parkinson's disease in twins: A 20-year update.
Ann Neurol
; 85(4): 600-605, 2019 04.
Article
em En
| MEDLINE
| ID: mdl-30786044
ABSTRACT
During the 1990s, we estimated the genetic contribution to Parkinson's disease risk in a large, population-based twin registry. Because many unaffected twins were still alive, previous concordance estimates were based on incomplete information. Ninety-five percent of twins are now deceased. Here, we update concordance and heritability through 2015 using National Death Index data. In total, we identified 30 concordant and 193 discordant pairs. Proband-wise concordance was 0.20 in monozygotic and 0.13 in dizygotic pairs. Heritability was 0.27 overall, 0.83 in pairs diagnosed ≤50, and 0.19 in pairs diagnosed >50. High concordance in dizygotic twins suggests shared effects of early childhood environment. Ann Neurol 2019;85600-605.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Gêmeos Dizigóticos
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Gêmeos Monozigóticos
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Predisposição Genética para Doença
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Doenças em Gêmeos
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Neurol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá