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[The role of actin cytoskeleton in regulating the deployment process of mouse cardiac second heart field progenitor cells].
Liu, Zhong Ying; Huang, Xia; Li, Zi Yi; Yang, Zi Hao; Yuan, Bai Yin.
Afiliação
  • Liu ZY; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
  • Huang X; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
  • Li ZY; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
  • Yang ZH; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
  • Yuan BY; College of Life Science and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Yi Chuan ; 41(2): 125-136, 2019 Feb 20.
Article em Zh | MEDLINE | ID: mdl-30803943
The vertebrate heart tube originates from cardiogenic mesodermal cells in the early embryo, and subsequently elongates by progressive addition of second heart field (SHF) progenitor cells from adjacent pharyngeal mesoderm and splanchnic mesoderm. Insufficient addition of SHF cells to the heart tube causes the failure of maximal elongation of the heart tube, which results in a series of developmental defects including the most common congenital birth defects, such as right ventricular dysplasia and outflow tract septation, and alignment anomalies. SHF cells form an atypical, apicobasally polarized epithelium which is characterized by apical monocilia, and dynamic actin-rich basal filopodia. In this review, we summarize recent research progresses of actin cytoskeleton in the deployment process of mouse SHF progenitor cells, and reveal the significance of actin cytoskeleton in SHF development, especially in the deployment of SHF cells to the outflow tract, to provide theoretical reference for elucidating and understanding the biological characteristics of SHF deployment.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Células-Tronco / Citoesqueleto de Actina / Coração / Mesoderma / Miocárdio Limite: Animals Idioma: Zh Revista: Yi Chuan Assunto da revista: GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Células-Tronco / Citoesqueleto de Actina / Coração / Mesoderma / Miocárdio Limite: Animals Idioma: Zh Revista: Yi Chuan Assunto da revista: GENETICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China