Cumambrin A prevents OVX-induced osteoporosis <i>via</i> the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways.

Zhou, Lin; Liu, Qian; Hong, Guoju; Song, Fangming; Zhao, Jinmin; Yuan, Jinbo; Xu, Jun; Tan, Ren Xiang; Tickner, Jennifer; Gu, Qiong; Xu, Jiake

Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways.

Zhou, Lin; Liu, Qian; Hong, Guoju; Song, Fangming; Zhao, Jinmin; Yuan, Jinbo; Xu, Jun; Tan, Ren Xiang; Tickner, Jennifer; Gu, Qiong; Xu, Jiake.

Afiliação

Zhou L; School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Liu Q; Department of Endocrinology, The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Hong G; School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Song F; Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.
Zhao J; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.
Yuan J; School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Xu J; Orthopedic Department, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Tan RX; School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Tickner J; Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.
Gu Q; Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Nanning, China.
Xu J; Research Centre for Regenerative Medicine, Guangxi Medical University, Nanning, China.

FASEB J ; 33(6): 6726-6735, 2019 06.

Article em En | MEDLINE | ID: mdl-30807230

Assuntos

Reabsorção Óssea/tratamento farmacológico; Osteoclastos/citologia; Osteogênese/efeitos dos fármacos; Osteoporose/prevenção & controle; Ovariectomia/efeitos adversos; Ligante RANK/metabolismo; Sesquiterpenos/farmacologia; Animais; Diferenciação Celular; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/genética; NF-kappa B/metabolismo; Osteoclastos/efeitos dos fármacos; Osteoporose/etiologia; Osteoporose/metabolismo; Osteoporose/patologia; Ligante RANK/genética; Células RAW 264.7; Transdução de Sinais

Palavras-chave

ERK; NF-κB; NFATc1; osteolysis

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Osteoclastos / Osteogênese / Osteoporose / Sesquiterpenos / Reabsorção Óssea / Ovariectomia / Ligante RANK Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

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