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Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes.
Seflek, H N; Kalkan, S; Cuce, G; Kilinc, I; Sozen, M E.
Afiliação
  • Seflek HN; a Departments of Histology and Embryology, Necmettin Erbakan University Meram Medical Faculty , Konya , Turkey.
  • Kalkan S; a Departments of Histology and Embryology, Necmettin Erbakan University Meram Medical Faculty , Konya , Turkey.
  • Cuce G; a Departments of Histology and Embryology, Necmettin Erbakan University Meram Medical Faculty , Konya , Turkey.
  • Kilinc I; b Department of Biochemistry, Necmettin Erbakan University Meram Medical Faculty , Konya , Turkey.
  • Sozen ME; c Department of Histology and Embryology, Faculty of Medicine, Alanya Alaaddin Keykubat University , Antalya , Turkey.
Biotech Histochem ; 94(5): 325-333, 2019 Jul.
Article em En | MEDLINE | ID: mdl-30821520
ABSTRACT
We investigated the effects of Nigella sativa oil on ovary volume, nuclear factor-kappaB (NF-κB), X-linked inhibitor of apoptosis protein (XIAP) expression, and serum malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS) levels in diabetic rats. We divided 21 adult female rats into three groups controls, diabetics and diabetics + N. sativa oil. The diabetics + N. sativa oil group was given 0.2 mg/kg/day N. sativa oil 6 days/week for 4 weeks. NF-κB and XIAP expression was assessed in ovarian sections using immunohistochemistry. The right and left ovary volumes were calculated using stereology. We also measured serum MDA, SOD, TAS and TOS levels. We found that N. sativa oil reduced hyperglycemia, but not to control levels. N. sativa oil also exhibited antioxidant properties as demonstrated by reduced serum TOS and MDA levels, and increased SOD and TAS levels compared to controls. We found no significant difference in total ovarian volume, XIAP or NF-κB expression among the groups, which may be due to the short study period. Our findings suggest that N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ovário / Óleos de Plantas / NF-kappa B / Diabetes Mellitus Experimental / Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X / Hiperglicemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotech Histochem Assunto da revista: HISTOCITOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Ovário / Óleos de Plantas / NF-kappa B / Diabetes Mellitus Experimental / Proteínas Inibidoras de Apoptose Ligadas ao Cromossomo X / Hiperglicemia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biotech Histochem Assunto da revista: HISTOCITOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia