Design, synthesis and biological evaluation of novel 2-phenyl pyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors.

Li, Xinyu; Shi, Binyu; Teng, Yu; Cheng, Yu; Yang, Huizhu; Li, Jiurong; Wang, Lianjian; He, Siying; You, Qidong; Xiang, Hua

Li, Xinyu; Shi, Binyu; Teng, Yu; Cheng, Yu; Yang, Huizhu; Li, Jiurong; Wang, Lianjian; He, Siying; You, Qidong; Xiang, Hua.

Afiliação

Li X; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Shi B; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Teng Y; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Cheng Y; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Yang H; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Li J; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Wang L; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
He S; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
You Q; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.
Xiang H; Jiangsu Key Laboratory of Drug Design and Optimization , China Pharmaceutical University , Nanjing 210009 , China . Email: xianghua@cpu.edu.cn ; ; Tel: +86 025 83271096.

Medchemcomm ; 10(2): 294-299, 2019 Feb 01.

Article em En | MEDLINE | ID: mdl-30881616

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: Medchemcomm Ano de publicação: 2019 Tipo de documento: Article