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Emergence of Low-level Delamanid and Bedaquiline Resistance During Extremely Drug-resistant Tuberculosis Treatment.
Polsfuss, Silke; Hofmann-Thiel, Sabine; Merker, Matthias; Krieger, David; Niemann, Stefan; Rüssmann, Holger; Schönfeld, Nicolas; Hoffmann, Harald; Kranzer, Katharina.
Afiliação
  • Polsfuss S; Institute for Microbiology, Immunology and Laboratory Medicine, Helios Klinikum Emil von Behring, Berlin.
  • Hofmann-Thiel S; Synlab Gauting, synlab MVZ Humane Genetik.
  • Merker M; IML red GmbH, Tuberculosis Supranational Reference Laboratory, Gauting.
  • Krieger D; Molecular and Experimental Mycobacteriology, Research Center Borstel.
  • Niemann S; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel.
  • Rüssmann H; Department of Pneumology, Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin.
  • Schönfeld N; Molecular and Experimental Mycobacteriology, Research Center Borstel.
  • Hoffmann H; German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Borstel.
  • Kranzer K; Institute for Microbiology, Immunology and Laboratory Medicine, Helios Klinikum Emil von Behring, Berlin.
Clin Infect Dis ; 69(7): 1229-1231, 2019 09 13.
Article em En | MEDLINE | ID: mdl-30933266
ABSTRACT
Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a patient with XDR tuberculosis.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oxazóis / Farmacorresistência Bacteriana / Tuberculose Extensivamente Resistente a Medicamentos / Diarilquinolinas / Mycobacterium tuberculosis / Nitroimidazóis / Antituberculosos Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oxazóis / Farmacorresistência Bacteriana / Tuberculose Extensivamente Resistente a Medicamentos / Diarilquinolinas / Mycobacterium tuberculosis / Nitroimidazóis / Antituberculosos Tipo de estudo: Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2019 Tipo de documento: Article