Unveiling the Kinomes of <i>Leishmania infantum</i> and <i>L. braziliensis</i> Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds.

Borba, Joyce V B; Silva, Arthur C; Ramos, Pablo I P; Grazzia, Nathalia; Miguel, Danilo C; Muratov, Eugene N; Furnham, Nicholas; Andrade, Carolina H

Unveiling the Kinomes of Leishmania infantum and L. braziliensis Empowers the Discovery of New Kinase Targets and Antileishmanial Compounds.

Borba, Joyce V B; Silva, Arthur C; Ramos, Pablo I P; Grazzia, Nathalia; Miguel, Danilo C; Muratov, Eugene N; Furnham, Nicholas; Andrade, Carolina H.

Afiliação

Borba JVB; Labmol - Laboratory for Molecular Modeling and Drug Design, Faculdade de Farmácia, Universidade Federal de Goiás - UFG, Goiânia, GO, 74605-510, Brazil.
Silva AC; Labmol - Laboratory for Molecular Modeling and Drug Design, Faculdade de Farmácia, Universidade Federal de Goiás - UFG, Goiânia, GO, 74605-510, Brazil.
Ramos PIP; Instituto Gonçalo Moniz (IGM), Fundação Oswaldo Cruz (FIOCRUZ), Salvador, BA, 40296-710, Brazil.
Grazzia N; LEBIL - Laboratory of Leishmania Biology Infection Studies, Department of Animal Biology, Biology Institute, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Miguel DC; LEBIL - Laboratory of Leishmania Biology Infection Studies, Department of Animal Biology, Biology Institute, State University of Campinas (UNICAMP), Campinas, SP, Brazil.
Muratov EN; Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599, USA.
Furnham N; Department of Chemical Technology, Odessa National Polytechnic University, Odessa, 65000, Ukraine.
Andrade CH; Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, London, UK.

Comput Struct Biotechnol J ; 17: 352-361, 2019.

Article em En | MEDLINE | ID: mdl-30949306

Palavras-chave

Drug repurposing; Kinases; Kinome; Leishmania braziliensis; Leishmania infantum; Target prioritization

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Texto completo: 1 Bases de dados: MEDLINE País/Região como assunto: America do sul / Brasil Idioma: En Revista: Comput Struct Biotechnol J Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil

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