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The molecular and cellular mechanisms of depression: a focus on reward circuitry.
Fox, Megan E; Lobo, Mary Kay.
Afiliação
  • Fox ME; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Lobo MK; Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA. mklobo@som.umaryland.edu.
Mol Psychiatry ; 24(12): 1798-1815, 2019 12.
Article em En | MEDLINE | ID: mdl-30967681
Depression is a complex disorder that takes an enormous toll on individual health. As affected individuals display a wide variation in their clinical symptoms, the precise neural mechanisms underlying the development of depression remain elusive. Although it is impossible to phenocopy every symptom of human depression in rodents, the preclinical field has had great success in modeling some of the core affective and neurovegetative depressive symptoms, including social withdrawal, anhedonia, and weight loss. Adaptations in select cell populations may underlie these individual depressive symptoms and new tools have expanded our ability to monitor and manipulate specific cell types. This review outlines some of the most recent preclinical discoveries on the molecular and neurophysiological mechanisms in reward circuitry that underlie the expression of behavioral constructs relevant to depressive symptoms.
Assuntos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Depressão Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Depressão Limite: Animals / Humans Idioma: En Revista: Mol Psychiatry Assunto da revista: BIOLOGIA MOLECULAR / PSIQUIATRIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos