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Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.
Ehsan, Muhammad; Kumar, Ashwani; Mortensen, Jonas S; Du, Yang; Hariharan, Parameswaran; Kumar, Kaavya K; Ha, Betty; Byrne, Bernadette; Guan, Lan; Kobilka, Brian K; Loland, Claus J; Chae, Pil Seok.
Afiliação
  • Ehsan M; Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.
  • Kumar A; Current address: Department of Chemistry, Mirpur University of Science&Technology (MUST), Mirpur-, 10250 (AJK), Pakistan.
  • Mortensen JS; Department of Bionanotechnology, Hanyang University, Ansan, 15588, Korea.
  • Du Y; Department of Neuroscience, University of Copenhagen, 2200, Copenhagen, Denmark.
  • Hariharan P; Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
  • Kumar KK; Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center Lubbock, TX, 79430, USA.
  • Ha B; Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
  • Byrne B; Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
  • Guan L; Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
  • Kobilka BK; Department of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, School of Medicine, Texas Tech University Health Sciences Center Lubbock, TX, 79430, USA.
  • Loland CJ; Molecular and Cellular Physiology, Stanford University, Stanford, CA, 94305, USA.
  • Chae PS; Department of Neuroscience, University of Copenhagen, 2200, Copenhagen, Denmark.
Chem Asian J ; 14(11): 1926-1931, 2019 Jun 03.
Article em En | MEDLINE | ID: mdl-30969484
We prepared an amphiphile with a penta-phenylene lipophilic group and a branched trimaltoside head group. This new agent, designated penta-phenylene maltoside (PPM), showed a marked tendency to self-assembly into micelles via strong aromatic-aromatic interactions in aqueous media, as evidenced by 1 H NMR spectroscopy and fluorescence studies. When utilized for membrane protein studies, this new agent was superior to DDM, a gold standard conventional detergent, in stabilizing multiple proteins long term. The ability of this agent to form aromatic-aromatic interactions is likely responsible for enhanced protein stabilization when associated with a target membrane protein.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Detergentes / Maltose / Proteínas de Membrana Idioma: En Revista: Chem Asian J Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
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Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Detergentes / Maltose / Proteínas de Membrana Idioma: En Revista: Chem Asian J Ano de publicação: 2019 Tipo de documento: Article