Integrin &#945;9 depletion promotes ß-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.

Wang, Zhishan; Li, Yunfei; Xiao, Yajuan; Lin, Hsuan-Pei; Yang, Ping; Humphries, Brock; Gao, Tianyan; Yang, Chengfeng

Integrin α9 depletion promotes ß-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.

Wang, Zhishan; Li, Yunfei; Xiao, Yajuan; Lin, Hsuan-Pei; Yang, Ping; Humphries, Brock; Gao, Tianyan; Yang, Chengfeng.

Afiliação

Wang Z; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY.
Li Y; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY.
Xiao Y; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY.
Lin HP; Cancer Center, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Yang P; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY.
Humphries B; Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, KY.
Gao T; School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, China.
Yang C; Department of Radiology, University of Michigan, Ann Arbor, MI.

Int J Cancer ; 145(10): 2767-2780, 2019 11 15.

Article em En | MEDLINE | ID: mdl-31008533

Assuntos

Integrinas/metabolismo; Recidiva Local de Neoplasia/patologia; Neoplasias de Mama Triplo Negativas/patologia; beta Catenina/metabolismo; Animais; Mama/patologia; Linhagem Celular Tumoral; Proliferação de Células; Biologia Computacional; Proteínas Quinases Dependentes de AMP Cíclico/metabolismo; Conjuntos de Dados como Assunto; Intervalo Livre de Doença; Regulação para Baixo; Feminino; Técnicas de Inativação de Genes; Quinase 3 da Glicogênio Sintase/metabolismo; Humanos; Integrinas/genética; Camundongos; Recidiva Local de Neoplasia/epidemiologia; Proteínas Serina-Treonina Quinases/metabolismo; Proteólise; RNA Interferente Pequeno/metabolismo; Transdução de Sinais; Análise de Sobrevida; Neoplasias de Mama Triplo Negativas/mortalidade

Palavras-chave

integrin α9; integrin-linked kinase; metastasis; protein kinase A; triple-negative breast cancer; ß-catenin

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Integrinas / Beta Catenina / Neoplasias de Mama Triplo Negativas / Recidiva Local de Neoplasia Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Int J Cancer Ano de publicação: 2019 Tipo de documento: Article

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