Your browser doesn't support javascript.
loading
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.
Alber, Jessica; Alladi, Suvarna; Bae, Hee-Joon; Barton, David A; Beckett, Laurel A; Bell, Joanne M; Berman, Sara E; Biessels, Geert Jan; Black, Sandra E; Bos, Isabelle; Bowman, Gene L; Brai, Emanuele; Brickman, Adam M; Callahan, Brandy L; Corriveau, Roderick A; Fossati, Silvia; Gottesman, Rebecca F; Gustafson, Deborah R; Hachinski, Vladimir; Hayden, Kathleen M; Helman, Alex M; Hughes, Timothy M; Isaacs, Jeremy D; Jefferson, Angela L; Johnson, Sterling C; Kapasi, Alifiya; Kern, Silke; Kwon, Jay C; Kukolja, Juraj; Lee, Athene; Lockhart, Samuel N; Murray, Anne; Osborn, Katie E; Power, Melinda C; Price, Brittani R; Rhodius-Meester, Hanneke F M; Rondeau, Jacqueline A; Rosen, Allyson C; Rosene, Douglas L; Schneider, Julie A; Scholtzova, Henrieta; Shaaban, C Elizabeth; Silva, Narlon C B S; Snyder, Heather M; Swardfager, Walter; Troen, Aron M; van Veluw, Susanne J; Vemuri, Prashanthi; Wallin, Anders; Wellington, Cheryl.
Afiliação
  • Alber J; Department of Biomedical and Pharmaceutical Sciences, George & Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA.
  • Alladi S; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.
  • Bae HJ; Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Barton DA; Department of Psychiatry, University of Melbourne, Melbourne, Australia.
  • Beckett LA; Department of Public Health Sciences, School of Medicine University of California, Davis, CA, USA.
  • Bell JM; Syneos Health, Wilmington, NC, USA.
  • Berman SE; Wisconsin Alzheimer's Disease Research Center, Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
  • Biessels GJ; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Black SE; Department of Medicine, University of Toronto, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Bos I; Department of Psychiatry & Neuropsychology, Alzheimer Centre Limburg, School for Mental Health & Neuroscience, Maastricht University, Maastricht, The Netherlands.
  • Bowman GL; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Brai E; Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.
  • Brickman AM; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
  • Callahan BL; Neuro-Bio Ltd, Culham Science Centre, Abingdon, UK.
  • Corriveau RA; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
  • Fossati S; Department of Psychology, University of Calgary & Hotchkiss Brain Institute, Calgary, AB, Canada.
  • Gottesman RF; Department of Psychology, University of Calgary & Hotchkiss Brain Institute, Calgary, AB, Canada.
  • Gustafson DR; Departments of Neurology and Psychiatry, NYU School of Medicine, New York, NY, USA.
  • Hachinski V; Division of Cerebrovascular Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hayden KM; Section for NeuroEpidemiology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA.
  • Helman AM; Western University, London Health Sciences Centre, London, ON, Canada.
  • Hughes TM; Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Isaacs JD; University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA.
  • Jefferson AL; Department of Internal Medicine - Section of Gerontology and Geriatric Medicine, and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Johnson SC; St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
  • Kapasi A; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Kern S; Department of Medicine-Geriatrics, Institute on Aging, University of Wisconsin-Madison, Madison, WI, USA.
  • Kwon JC; Department of Pathology (Neuropathology), Rush Alzheimer's Disease Center, Chicago, IL, USA.
  • Kukolja J; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
  • Lee A; Department of Neurology, Changwon Fatima Hospital, Changwon, Korea.
  • Lockhart SN; Department of Neurology and Clinical Neurophysiology, Helios University Hospital Wuppertal, Wuppertal, Germany.
  • Murray A; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.
  • Osborn KE; Department of Internal Medicine - Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Power MC; Berman Center for Outcomes and Clinical Research, 20298 Minneapolis Medical Research Foundation, Minneapolis, MN, USA.
  • Price BR; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Rhodius-Meester HFM; Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
  • Rondeau JA; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.
  • Rosen AC; Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam Neuroscience, Amsterdam, The Netherlands.
  • Rosene DL; Montclair Memory Clinic, Montclair, NJ, USA.
  • Schneider JA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Scholtzova H; Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA.
  • Shaaban CE; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA.
  • Silva NCBS; Department of Neurology, NYU School of Medicine, New York, NY, USA.
  • Snyder HM; Department of Epidemiology, Graduate School of Public Health & Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA.
  • Swardfager W; School of Kinesiology, Western Centre for Public Health & Family Medicine, London, ON, Canada.
  • Troen AM; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA.
  • van Veluw SJ; Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Vemuri P; Institute of Biochemistry Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture Food and Environment, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Wallin A; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Wellington C; Department of Radiology, Mayo Clinic Rochester, Rochester, MN, USA.
Alzheimers Dement (N Y) ; 5: 107-117, 2019.
Article em En | MEDLINE | ID: mdl-31011621
ABSTRACT
White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement (N Y) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Alzheimers Dement (N Y) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos