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A Diene-Containing Noncanonical Amino Acid Enables Dual Functionality in Proteins: Rapid Diels-Alder Reaction with Maleimide or Proximity-Based Dimerization.
St Amant, Andre H; Huang, Fengying; Lin, Jia; Rickert, Keith; Oganesyan, Vaheh; Lemen, Daniel; Mao, Shenlan; Harper, Jay; Marelli, Marcello; Wu, Herren; Gao, Changshou; Read de Alaniz, Javier; Christie, R James.
Afiliação
  • St Amant AH; Department of Chemistry and Biochemistry, University of California - Santa Barbara, Santa Barbara, California, 93106, USA.
  • Huang F; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Lin J; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Rickert K; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Oganesyan V; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Lemen D; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Mao S; AstraZeneca Oncology R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Harper J; AstraZeneca Oncology R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Marelli M; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Wu H; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Gao C; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Read de Alaniz J; Department of Chemistry and Biochemistry, University of California - Santa Barbara, Santa Barbara, California, 93106, USA.
  • Christie RJ; Antibody Discovery and Protein Engineering Department, AstraZeneca Biopharmaceuticals R&D, One MedImmune Way, Gaithersburg, MD, 20878, USA.
Angew Chem Int Ed Engl ; 58(25): 8489-8493, 2019 06 17.
Article em En | MEDLINE | ID: mdl-31018033
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Imunoglobulina G / Fragmentos Fc das Imunoglobulinas / Alcadienos / Aminoácidos / Maleimidas Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Imunoglobulina G / Fragmentos Fc das Imunoglobulinas / Alcadienos / Aminoácidos / Maleimidas Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos