Development of a Universal Fluorescent Probe for Gram-Positive Bacteria.
Angew Chem Int Ed Engl
; 58(25): 8426-8431, 2019 06 17.
Article
em En
| MEDLINE
| ID: mdl-31025486
ABSTRACT
The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the best universal selectivity for Gram-positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram-positive bacterial infection, not only inâ
vitro but also using an inâ
vivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
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Bases de dados:
MEDLINE
Assunto principal:
Corantes Fluorescentes
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Bactérias Gram-Positivas
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Ceratite
Limite:
Animals
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2019
Tipo de documento:
Article