Inhibitory Effect of Olive Leaf Extract on Obesity in High-fat Diet-induced Mice.
In Vivo
; 33(3): 707-715, 2019.
Article
em En
| MEDLINE
| ID: mdl-31028187
ABSTRACT
BACKGROUND/AIM:
The rapid increase in the number of people who are overweight or obese, which increases the risk of diseases and health problems, is becoming an important issue. Herein, we investigated whether olive leaf extract (OLE) has potent anti-obesity effects in high-fat induced mouse models. MATERIALS ANDMETHODS:
C57BL/6 mice were randomized into normal control, high-fat diet (HFD), HFD with OLE, and HFD with garcinia groups and administered experimental diets for 12 weeks. Body weight and food intake were measured once per week and obesity-related biomarkers were evaluated in the serum and adipose tissue.RESULTS:
OLE significantly suppressed weight gain, food efficiency ratio, visceral fat accumulation, and serum lipid composition in HFD-induced mice. Furthermore, the expression of adipogenesis- and thermogenesis-related molecules was decreased in the OLE-treated group.CONCLUSION:
OLE prevents obesity development by regulating the expression of molecules involved in adipogenesis and thermogenesis.Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Folhas de Planta
/
Fármacos Antiobesidade
/
Olea
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
In Vivo
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2019
Tipo de documento:
Article