Effects of Silymarin on the In Vivo Pharmacokinetics of Simvastatin and Its Active Metabolite in Rats.

Li, Ying; Wu, Yin; Li, Ya-Jing; Meng, Lu; Ding, Cong-Yang; Dong, Zhan-Jun

Li, Ying; Wu, Yin; Li, Ya-Jing; Meng, Lu; Ding, Cong-Yang; Dong, Zhan-Jun.

Afiliação

Li Y; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. lyyaoda@126.com.
Wu Y; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. wuyin831@126.com.
Li YJ; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. 15369305382@163.com.
Meng L; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. M18203213683@163.com.
Ding CY; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. dingcy1989@126.com.
Dong ZJ; National Clinical Drug Monitoring Center, Department of Pharmacy, Hebei Province General Center, Shijiazhuang 050051, China. dzjhbgh@126.com.

Molecules ; 24(9)2019 Apr 28.

Article em En | MEDLINE | ID: mdl-31035343

Assuntos

Interações Medicamentosas; Inibidores de Hidroximetilglutaril-CoA Redutases/farmacocinética; Metabolômica; Silimarina/farmacologia; Sinvastatina/farmacocinética; Animais; Metabolômica/métodos; Estrutura Molecular; Ratos

Palavras-chave

herb-drug interaction; pharmacokinetics; silymarin; simvastatin; simvastatin hydroxyacid

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Silimarina / Inibidores de Hidroximetilglutaril-CoA Redutases / Sinvastatina / Interações Medicamentosas / Metabolômica Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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