Your browser doesn't support javascript.

Portal de Pesquisa da BVS Enfermagem

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
XML
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

Health-related quality of life in long-term survivors with localised prostate cancer by therapy-Results from a population-based study.

Adam, Salome; Koch-Gallenkamp, Lena; Bertram, Heike; Eberle, Andrea; Holleczek, Bernd; Pritzkuleit, Ron; Waldeyer-Sauerland, Mechthild; Waldmann, Annika; Zeissig, Sylke Ruth; Rohrmann, Sabine; Brenner, Hermann; Arndt, Volker.
Eur J Cancer Care (Engl) ; 28(5): e13076, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31050091

OBJECTIVE:

Several therapies for localised prostate cancer (PC) are available; all yield similar survival rates. However, each therapy has significant side effects that can influence patients' health-related quality of life (HRQoL) in the long run.

METHODS:

The study sample included 911 survivors with localised PC, 5-15 years post-diagnosis who were identified from the population-based CAESAR + study in Germany. HRQoL was assessed using the EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. The association between type of therapy and HRQoL was assessed with multivariable linear regression and global F-test adjusting for age, time since diagnosis and comorbidities.

RESULTS:

Overall, survivors treated with radical prostatectomy (RP) or radiotherapy (RT) alone reported the best HRQoL and the lowest symptom burden. Conversely, survivors treated with androgen deprivation therapy (ADT) (& RP/RT) or RP & RT (in combination) reported the worst HRQoL and the highest symptom burden. Significant differences among treatment groups in HRQoL were found for global health status (p = 0.041), social functioning (p = 0.007), urinary symptoms (p = 0.035), bowel symptoms (p = 0.017) and hormonal treatment-related symptoms (p < 0.001) among other symptoms.

CONCLUSIONS:

Long-term localised PC survivors formerly treated with a combination of RP and RT or with ADT report poorer HRQoL and more symptoms than patients treated with either RP or RT alone.